Towards understanding mechanisms of autoimmune bullous skin diseases

New Observations in Autoimmune Bullous Skin Diseases

Bullous Skin Diseases: Classical Types of Autoimmune Diseases

The prototypic bullous skin diseases, pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid, are characterized by the blister formation in the skin and/or oral mucosa in combination with circulating and deposited autoantibodies reactive with (hemi)desmosomes. Koch's postulates, adapted for autoimmune diseases, were applied on these skin diseases. It appears that all adapted Koch's pos...

Immunofluorescence Pattern of Autoimmune Bullous Diseases in Iranian Patients

Background & Objective: Autoimmune bullous diseases are associated with autoimmunity against structural components in the skin and mucous membranes. Autoantibodies are against the intercellular junctions in pemphigus disease and hemidesmosomal unchoring complex in pemphigiod diseases and epidermolysis bullosa aquisita. The tissue-bound and circulating serum autoantibodies can be detect...

Therapy of autoimmune bullous diseases

Autoimmune bullous diseases result from an immune response to molecular components of the desmosome or basement membrane. Bullous diseases are associated with a high degree of morbidity and occasional mortality. Therapy of bullous diseases consists of suppressing the immune system, controlling inflammation and improving healing of erosions. The therapeutic agents used in the treatment of bullou...

The Spectrum of Autoimmune Bullous Diseases

Autoimmune bullous diseases are a group of cutaneous disorders characterised by skin blistering or erosions as a result of development of autoimmunity. It can be classified according to the anatomical sites of blister into two types: intraepithelial and subepidermal. It can be subdivided further according to the clinical features, type and location of immunoreactants found on skin biopsy (Table...